Bipolar Disorder

Information on Bipolar Disorder

Bipolar disorder also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a person's mood, energy, and ability to function. Different from the normal ups and downs that everyone goes through, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and even suicide. Resources on Mood issues and Bipolar Disorder include: The Bipolar Child (2002) Demitri Papolos, and Janice Papolos by Broadway Books, NY and Raising a Moody Child: How to Cope with Depression and Bipolar Disorder (2004) by Mary Fristad and Jill Golberg Arnold by Guilford Press.

An Unquiet Mind: Memoir of Moods and Madness by Dr. Kay Redfield Jamison  details Dr. Jamison's life and experience with Bipolar Disorder.  Dr. Jamison is a noted researcher on mood disorders.  This book is an excellent resource on both the personal and medical side of Bipolar Disorder.






Information on the internet can be found at link to NIMH.

Speaking of Science- Dr. Ellen Leibenluft: The Warning Signs of Childhood Bipolar Spectrum Disorder

      Suicide Risk Factors in Bipolar Disorder Identified

      4/4/17
      Medscape reports that "Patients with bipolar disorder (BD) with depressed polarity, comorbid anxiety, and an anxious temperament may be at increased risk for suicide, new research suggests. "Hyperthymic temperament in our population might be a protective factor against suicidality in bipolar patients, whereas depressed polarity, anxiety comorbidity, and anxious temperament seem to elevate the risk for suicidality. So, especially in these patient subgroups, suicidality should be closely monitored," the investigators, led by Uta Ouali, MD, Razi Hospital, Mannouba, Tunisia, report. The findings were presented here at the European Psychiatric Association (EPA) 25th Congress."
      Click this link to read about the study.

      New Guidance on Ketamine for Mood Disorders

      3/2/17
      Medscape reports that "An expert consensus statement aimed at helping physicians safely and appropriately administer the anesthetic ketamine (Ketalar, Par Sterile Products) for the treatment of severe depression and other mood disorders has been issued, at least in part in response to the growing and ungoverned off-label use of the drug by ketamine clinics throughout the United States. "There is clear evidence that the use of ketamine for the treatment of mood disorders is increasing rapidly around the country, and there was a need for some guidance around what we know so, at a minimum, there will be some information out there for clinicians who are interested in either referring people or using the treatment themselves," the statement's lead author, Gerard Sanacora, MD, PhD, professor of psychiatry and director of the Yale Depression Research Program, New Haven, Connecticut, told Medscape Medical News."
      Click this link to read about the study.
      Click this link to read more about the study.

      Omega-3 Fatty Acids Plus Inositol Promising in Pediatric BPD

      7/4/14
      New research shows that the combination of high EPA (eicosapentaenoic acid) omega-3 fatty acids and inositol appears to be promising in the treatment of prepubertal children with bipolar spectrum disorders, a pilot study suggests.
      Click this link to read more about the study.

      Flu in Pregnancy May Quadruple Child’s Risk for Bipolar Disorder

      5/29/13
      Pregnant mothers’ exposure to the flu was associated with a nearly fourfold increased risk that their child would develop bipolar disorder in adulthood, in a study funded by the National Institutes of Health. The findings add to mounting evidence of possible shared underlying causes and illness processes with schizophrenia, which some studies have also linked to prenatal exposure to influenza.
      “Prospective mothers should take common sense preventive measures, such as getting flu shots prior to and in the early stages of pregnancy and avoiding contact with people who are symptomatic,” said Alan Brown, M.D., M.P.H, of Columbia University and New York State Psychiatric Institute, a grantee of the NIH’s National Institute of Mental Health (NIMH). “In spite of public health recommendations, only a relatively small fraction of such women get immunized. The weight of evidence now suggests that benefits of the vaccine likely outweigh any possible risk to the mother or newborn.”
      Click this link to read more about the study.
      Click this link to read an abstract of the article.

      In-Scanner Tasks Reveal Divergences with Overlapping Disorders

      5/16/10
      New Brain study finds that some children with chronic irritablilty and some bipolar traits actually present with a different disorder. Researchers have theorized that these severely irritable children without clear episodes of bipolar mood swings have a syndrome they call Severe Mood Dysregulation (SMD). They hypothesize that children with SMD share certain overlapping features with their bipolar peers, such as poor frustration tolerance and impaired ability to recognize emotional facial expressions, but differ in symptoms, course, and pedigree.

      Earlier studies by this research team have shown that children with Bipolar Disorder tend to come from families with histories of the disorder and tend to carry the disorder into adulthood, while children with SMD don't. They have found that children with SMD are more prone to developing depression or anxiety disorders rather than BD as adults.

      Increased Risk May Stem From Variation in Gene On/Off Switch

      2/2/09
      New research finds that the same genes are suspected in both Depression and Bipolar Illness
      Click this link to read the article..

      Children at risk if parents Bipolar

      2/2/09
      Children of Parents with Bipolar Disorder at greater risk for Bipolar Disorder and of early onset of the disorder. New studies suggest that children with Bipolar Disorder who have parents with Bipolar Disorder may present with the condition on average 6 years earlier than their parents were first diagnosed.

      Significant Weight Gain, Metabolic Changes Associated with Antipsychotic Use in Children

      10/29/09
      A new research study has confirmed what many patients and families have experienced. The study finds that Antipsychotic medications when used with children often lead to significant weight gain. This does not mean the medicines should not be used, but that these issues need to be discussed with your child's pediatrician, doctor, or psychiatrist.

      Bipolar Disorder in Adults

      7/18/09
      Booklet on Bipolar Disorder: a detailed booklet from the NIMH that describes Bipolar Disorder symptoms, causes, and treatments, with information on getting help and coping.

      Symptoms Persist as Bipolar Children Grow Up

      11/5/08
      Research: Symptoms Persist as Bipolar Children Grow-up

Bipolar Disorder Quicklinks

NIH What is Bipolar Disorder.




© Copyright, all rights reserved Daniel J. DeMarle, Ph.D. 2014